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文献和实验Circulating Tumor Cells as Prognostic Biomarkers in Cutaneous Melanoma Patients
without the need of separating CTC from leukocytes (PBL). We selected and optimized four mRNA biomarkers (MART-1/Melan-A, MAGE-A3, PAX3, and GalNAc-T) for detection and prediction of clinical outcome in melanoma patients. Our protocol has both high sensitivity and specificity
抗原有多种分类方法,其中被普遍接受的有两类方法。 一、根据肿瘤抗原特异性的分类 根据肿瘤抗原的特异性,可将肿瘤抗原分为肿瘤特异性抗原(tumor specific antigen, TSA)和肿瘤相关抗原(tumor associated antigen, TAA)。 (一)肿瘤特异性抗原 TSA仅表达于肿瘤组织,而不存在于正常组织。此类抗原乃通过肿瘤在同种系动物间的移植而被证实(图18
Analysis of Interdomain Interactions of the Androgen Receptor
, it has an inhibitory effect on transcriptional activity from AF2 by competing for p160 coactivator LXX LL motif binding. The primate-specific AR coregulatory protein, melanoma antigen gene protein-A11 (MAGE-A11), modulates the AR N/C interaction through a direct
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