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文献和实验Differential Expression of Apoptosis-Associated Genes bax and bcl-2 in Ovarian Cancer
either as inhibitors (e.g., bcl-2, bcl-xl, mcl- 1) or promoters (e.g., bcl-xs, bax, bak, bad) of apoptosis (1 -3 ). The chromosomal translocation t(14;18), leading to overexpression of the Bcl-2 protein was first described in human B-cell lymphoma (4 ). Later
Bcl-2蛋白是bcl-2 原癌基因的编码产物,是细胞存活促进因子,属膜整合蛋白,分子量为26kDa, 定位于线粒体、内质网和连续的核周膜。Bcl-2蛋白家族是一个特别的家族,成员中有些促进凋亡,如Bad、Bid 、Bax,有些成员阻止细胞凋亡,如Bcl-2、 Bcl-x、Bcl-w。Bcl-2能够阻止细胞色素c从线粒体释放到细胞质,从而抑制了细胞凋亡。
Molecular Characterization of the Proapoptotic Protein Bax
Bax is a proapoptotic member of the Bcl-2 family. Members of this family can promote either cell survival, as in the case of Bcl-2 and Bcl-XL , or cell death, as in the case of Bax and Bak. Bax was first identified as a Bcl-2 binding partner
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