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文献和实验Metabolism of arachidonic acid results in formation of eicosanoids including prostaglandins (PGs), thromboxanes (Txs), monohydroxyeicosatetraenocinoids (HETEs), leukotrienes (LTs), lipoxins (Lxs), epoxy metabolites, and hepoxilins
Quantitative Analysis of Cyclooxygenase Metabolites of Arachidonic Acid
to regioisomeric epoxides and stereo specific hydro xyeicosatetraenoic (HETE) acids ( 6 ). Fig. 1. Overview of pathways of metabolism of arachidonic acid during airway inflammation. Following activation of cellular phospholipases
that are reduced to lipid alcohol, such as hydroxyeicosatetraenoic acid (HETEs), and isoprostanes (IsoPs) respectively. The IsoPs are isomers of prostaglandins that are generated from autoxidation of arachidonic acid (C20:4). Quantification of F2 -IsoPs
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