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文献和实验Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators
The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a wide range of biological and toxicological effects from exposure to structurally diverse synthetic and naturally occurring chemicals. The role of the AhR
. GRA of the aryl hydrocarbon receptor (AhR) relies on the in vitro ability of the cytosolic AhR protein complex to convert into its high affinity DNA binding form following its interaction with and activation by an AhR agonist and, as such, the GRA
益生菌竟然有害健康?破坏免疫抑制,刺激肿瘤生长,化身「癌症帮凶」
乳酸菌,是酸奶界赫赫有名的大人物,在人们的传统认知里是促进胃肠道功能的有益菌群,但是没想到啊没想到,这「浓眉大眼」 的乳酸菌也背叛革命了,竟然成为了胰腺癌的「帮凶」。 2022 年 2 月 8 日,加拿大多伦多大学 Tracy L. McGaha 团队在 Cell 子刊 Immunity 上发表了题为 Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor
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