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文献和实验Molecular Typing of the MHC Class I Chain-Related Gene Locus
The human major histocompatibility complex (MHC) class I chain-related genes A and B (MICA and MICB ) are located within the human leukocyte antigen (HLA) class I region of chromosome 6 (1 ). Their organization, expression, and products
High Resolution MICA Genotyping by Sequence-Based Typing (SBT)
We have developed a MICA typing method based on polymerase chain reaction (PCR) sequence-based typing and a computer program that determines the polymorphisms and distinguishes the GCT repeats in exon 5. One PCR amplification was performed
基因。HLA-F基因位于HLA-C基因外侧。HLA-G基因位于HLA-A座位远侧,被正式命名的等位基因已有23个。 (3)MIC基因:MIC(MHCclassl chain-related)基因是1994年发现的+个家族,目前有5个成员,分别命名为MICA、MICB、MICC、MICD和MICE。其中MICA和MICB为功能基因,余为假基因。MICA基因定位在HLA-B基因着丝粒方向40kb处,是HLA-B基因最近的邻居,且MICA具有高度多态性,等位基因数达61个,与HLA―B存在连锁不平
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