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文献和实验Pyrogenic, Lethal, and Emetic Properties of Superantigens in Rabbits and Primates
of pyrogenic toxins, and various members of this group of SAgs have a clear involvement in the toxic shock syndrome (TSS). Through SAg-mediated stimulation, Tlymphocytes are activated at several orders of magnitude above antigen-specific activation, resulting
Role of Accessory Molecules in the Superantigen-Induced Activation of Peripheral Blood T Cells
(5 ). This T-cell activation by SAg has been described as being MHC class II molecule-dependent (although unrestricted). However, the expression of MHC class II molecules on some antigen-presenting cells (APCs) is not always sufficient to induce a T-cell
Assessment of Specific T-Cell Activation by Superantigens
The main characteristic of a superantigen (SAg) is that it activates specific subsets of T cells that are composed of particular T-cell receptor (TCR) variable region β chain gene products (TCRBV). SAgs are thought to form a bridge
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