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- DIMA BIOTECH/缔码生物
- 武汉
- PME49077
- 2025年07月12日
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- 保存条件：
-80°C
- 保质期：
请咨询
- 英文名：
Human Muscarinic Acetylcholine Receptor M3 (CHRM3) (NM_000740) Protein
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
50 ug
| 产品类别 | ECD Proteins |
|---|---|
| 靶点 | Muscarinic Acetylcholine Receptor M3 |
| Uniprot ID | P20309 |
| 背景 | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016] |
| 描述 | Purified recombinant protein of Human cholinergic receptor, muscarinic 3 (CHRM3), Arg253-Gln491, with N-terminal His tag, expressed in E.coli, 50ug |
| 分子量 | 26.6 kDa |
| 纯度 | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| 别名 | EGBRS; HM3; PBS |
| 标签 | N-His |
| 表达宿主 | E. coli |
| 组分与重悬 | 50mM Tris, 8M Urea, pH8.0. |
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文献和实验Overview of Receptor Allosterism
Figure 1.21.1 Allosterism between a receptor and its G protein: the effects of GTP on the competition between [3 H] N ‐methylscopolamine and the agonist, carbachol, at the muscarinic acetylcholine M2 receptor in rat myocardial membranes. Competition
Discovering Cell Type-Specific Patterns of G Protein-Coupled Receptor Phosphorylation
of M3 -muscarinic receptor phosphorylation.
Assessment of Receptor Internalization and Recycling
molecule GPCRs such as muscarinic acetylcholine and adrenergic receptors has been measured using hydrophilic antagonist radioligands that are membrane impermeant. In contrast, internalization of peptide hormone receptors is assessed by measuring
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