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文献和实验Discovery and Function of the Very Large G Protein-Coupled Receptor
The very large G protein-coupled receptor 1 (VLGR1), also known as MASS1 or GPR98, is most notable among the family of adhesion GPCR for its size. Encoded by an 18.9 kb open reading frame, the ~700 kDa primary translation product is by far
The HIV-1 entry receptors are CD4 and a chemokine receptor (CCR5 or CXCR4). In addition it has recently been demonstrated that HIV-1 gp120 binds to and signals through integrin α4 β7 , the gut-homing receptor (Arthos et al., Nat Immunol
Historically, the G protein-coupled receptor (GPCR) protein family has proven to be an extremely tractable target class (1 ). It is estimated that approximately one-half of all drugs currently marketed exert their actions, either directly
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