LAU-0901

一种PAF受体拮抗剂；在30、60和90mg/kg剂量下，可减少MCAO诱发的脑缺血大鼠模型中的梗塞体积并改善神经功能；在同一模型中减少小胶质细胞浸润并增加星形胶质细胞和神经元的存活率；在U87MG小鼠原位肿瘤模型中，单独使用30mg/kg或与阿托伐他汀联合使用可减少肿瘤生长。A PAF receptor antagonist; reduces infarct volume and improves neurological function in a rat model of MCAO-induced cerebral ischemia at 30, 60, and 90 mg/kg; reduces microglial infiltration and increases astrocytic and neuronal survival in the same model; reduces tumor growth in a U87MG mouse orthotopic tumor model at 30 mg/kg alone or in combination with atorvastatin.分子式C29H39Cl2N3O7分子量612.5O=C(C1=C(C)NC(C)=C(C1C)C(OC(CN2CCOCC2)CN3CCOCC3)=O)OCCOC4=CC=C(C(Cl)=C4)Cl