Tat-AKAP79 (326-336) (trifluor

一种肽；浓度为200µM时可抑制大鼠DRG分离神经元中PKA或PKC激活引起的TRPV1敏化；抑制小鼠福尔马林或PMA诱发的痛觉行为；增加辐射热刺激引起的缩爪潜伏期，并增加角叉菜胶诱发的炎症疼痛小鼠模型中缩爪的机械阈值力。A peptide; inhibits PKA or PKC activation-induced sensitization of TRPV1 in isolated rat DRG neurons at 200 µM; inhibits formalin- or PMA-induced nocifensive behavior in mice; increases the latency to paw withdrawal from a radiant heat stimulus and increases the mechanical threshold force to paw withdrawal in a mouse model of carrageenan-induced inflammatory pain.分子式C117H211N49O34S • XCF3COOH分子量2880.3O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC1=CC=C(O)C=C1)N[H].OC(C(F)(F)F)=O