PNU 159682

奈莫柔比星的活性代谢物；形成DNA加合物；抑制多种癌细胞系的增殖(IC70s=0.075-0.577nM)；在MX-1乳腺癌小鼠异种移植模型中，以4µg/kg的剂量减小肿瘤体积；已用于合成ADC的细胞毒性有效载荷部分。An active metabolite of nemorubicin; forms DNA adducts; inhibits the proliferation of several cancer cell lines (IC70s = 0.075-0.577 nM); reduces tumor volume in an MX-1 breast cancer mouse xenograft model at 4 µg/kg; has been used in the synthesis of cytotoxic payload moieties of ADCs.分子式C32H35NO13分子量641.6OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@]6([H])N7[C@]([C@H](OCC7)OC)([H])O[C@]6([H])[C@@H](O5)C