JG-98

Hsp70-BAG-3蛋白质-蛋白质相互作用的抑制剂(IC50=1.6µM)；降低MDA-MB-231和MCF-7细胞(EC50s分别为0.4和0.7µM)以及其他22种癌细胞系(EC50s=0.3-4µM)的增殖；对MEF有毒性(EC50=22µM)；以每两天3mg/kg的剂量降低MCF-7乳腺癌和HeLa宫颈癌小鼠异种移植模型中的肿瘤生长。An inhibitor of the Hsp70-BAG-3 protein-protein interaction (IC50 = 1.6 µM); reduces the proliferation of MDA-MB-231 and MCF-7 cells (EC50s = 0.4 and 0.7 µM, respectively) and 22 other cancer cell lines (EC50s = 0.3-4 µM); toxic to MEFs (EC50 = 22 µM); reduces tumor growth in MCF-7 breast cancer and HeLa cervical cancer mouse xenograft models at 3 mg/kg every two days.分子式C24H21ClN3OS3 • Cl分子量534.5CN1/C(SC2=C1C=CC(Cl)=C2)=C3S/C(N(CC)C\3=O)=C\C4=[N+](CC5=CC=CC=C5)C=CS4.[Cl-]