Moexiprilat

血管紧张素转换酶(ACE)抑制剂和前药莫昔普利(IC50=2.1nM)的活性代谢物；在10nM时可阻止雌酮或血管紧张素II刺激的原代新生大鼠心脏成纤维细胞增殖；在每天50mg/kg的剂量下可降低卵巢切除小鼠的平均动脉血压并增加心房利钠肽的水平。An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day.分子式C25H30N2O7分子量470.5C[C@H](N[C@H](C(O)=O)CCC1=CC=CC=C1)C(N2CC3=CC(OC)=C(OC)C=C3C[C@H]2C(O)=O)=O