Triciribine Phosphate

Akt活化抑制剂和曲西立滨的活性代谢物；与Akt的PH结构域结合并阻止其在MDA-MB-468细胞中募集到质膜；降低A1847和A2780细胞的增殖（IC50s分别为1.6和18µM）；抑制CEM-SS细胞中的HIV-1逆转录酶活性（IC50=0.04µM），以及BS-C-1细胞中的HSV-1复制和HFF-1IRR细胞中的人类CMV斑块形成（IC50s分别为20和0.8µM）。An Akt activation inhibitor and active metabolite of triciribine; binds to the PH domain of Akt and prevents its recruitment to the plasma membrane in MDA-MB-468 cells; reduces the proliferation of A1847 and A2780 cells (IC50s = 1.6 and 18 µM, respectively); inhibits HIV-1 reverse transcriptase activity in CEM-SS cells (IC50 = 0.04 µM), as well as HSV-1 replication in BS-C-1 cells and human CMV plaque formation in HFF-1 IRR cells (IC50s = 20 and 0.8 µM, respectively).分子式C13H17N6O7P分子量400.3O=P(O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C3C(C2=NC=N4)=C4N(C)N=C3N)O1