STOML3 Inhibitor OB-1

STOML3寡聚化抑制剂；在无细胞测定中以10µM浓度抑制小鼠和人类STOML3的寡聚化；降低Neuro2a细胞中的Piezo1通道电流幅度；抑制野生型小鼠的触觉感知并减轻链脲佐菌素诱发的糖尿病神经病变小鼠模型中的触觉异常性疼痛。An inhibitor of STOML3 oligomerization; inhibits oligomerization of mouse and human STOML3 in cell-free assays at 10 µM; reduces Piezo1 channel current amplitude in Neuro2a cells; inhibits tactile perception in wild-type mice and reduces tactile allodynia in a mouse model of streptozotocin-induced diabetic neuropathy.分子式C21H17N3O6分子量407.4O=C(C1=C(C2=CC=CC=C2)OC3=C1C=C(OC4=C([N+]([O-])=O)N=CN4C)C=C3)OCC