MK-8722

AMPK激活剂；0.1和10µM时激活Ampk并增加小鼠原代DRG中的磷酸化Acc1水平；20和50µM时降低PANC-1和PaTu 8988胰腺癌细胞的增殖、集落形成、迁移和侵袭并诱导其凋亡；50µM时诱导PANC-1和PaTu 8988癌细胞的细胞周期停滞于G2期；每天25mg/kg时减少PANC-1小鼠异种移植模型中的肿瘤体积和重量；10和30mg/kg时降低高脂饮食诱发的糖尿病小鼠模型中禁食和葡萄糖激发小鼠的血糖水平；30mg/kg时增加小鼠在vonFrey测试中的爪子缩回阈值。An AMPK activator; activates Ampk and increases phosphorylated Acc1 levels in primary mouse DRG at 0.1 and 10 µM; reduces the proliferation, colony formation, migration, and invasion of, and induces apoptosis in, PANC-1 and PaTu 8988 pancreatic cancer cells at 20 and 50 µM; induces cell cycle arrest at the G2 phase in PANC-1 and PaTu 8988 cancer cells at 50 µM; reduces tumor volume and weight in a PANC-1 mouse xenograft model at 25 mg/kg per day; decreases blood glucose levels in fasting and glucose-challenged mice in a mouse model of diabetes induced by a high-fat diet at 10 and 30 mg/kg; increases the paw withdrawal threshold in the von Frey test in mice at 30 mg/kg.分子式C24H20ClN3O4分子量449.9ClC1=C(C2=CC=C(C3=CC=CC=C3)C=C2)N=C(C(N4)=C1)N=C4O[C@H]5[C@]6([H])[C@]([C@@H](CO6)O)([H])OC5