A20FMDV2 (trifluoroacetate sal

一种肽类化合物，能够抑制αvβ6整合素依赖的细胞黏附，其在表达人αvβ6整合素的H357细胞中表现出抑制活性，IC50值为1.2µM。当与111In-DTPA偶联时，A20FMDV2能够结合内源性表达的αvβ6整合素，并用于乳腺癌小鼠异种移植模型（MCF10CA1a）的放射性成像分析，剂量为20MBq。A peptide; inhibits αVβ6 integrin-dependent cell adhesion in H357 cells expressing human αVβ6 (IC50 = 1.2 µM); When coupled with 111indium-DTPA, A20FMDV2 binds to αVβ6 integrin endogenously expressed for radiation imaging analysis in a MCF10CA1a breast cancer mouse xenograft model at 20 MBq.分子式C93H163N31O28 • XCF3COOH分子量2163.5OC(C(F)(F)F)=O.O=C(N[C@H](C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](O)C)([H])C(O)=O)=O)=O)C)=O)=O)=O)=O)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)C)[C@H](CC(N)=O)N[H]