Fz7-21 (trifluoroacetate salt)

FZD7受体的肽拮抗剂(IC50=100nM)；在使用HEK293细胞的报告检测中抑制Wnt3a诱导的β-catenin信号传导；在100µM时减少小鼠原代肠道类器官中Lrg5阳性细胞的数量和编码Ash-2和Axin2的mRNA，并增加编码Muc2的mRNA。A peptide antagonist of the FZD7 receptor (IC50 = 100 nM); inhibits Wnt3a-induced β-catenin signaling in a reporter assay using HEK293 cells; reduces the number of Lrg5-positive cells and the mRNA encoding Ash-2 and Axin2 and increases mRNA encoding Muc2 in primary mouse intestinal organoids at 100 µM.分子式C83H114N18O23S2 • XCF3COOH分子量1796O=C([C@H]1N(CCC1)C([C@@H](NC(C)=O)CC(C)C)=O)N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N[C@H](C(N)=O)CC3=CC=C(C=C3)O)=O)=O)=O)CC4=CN=CN4)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O