Verdiperstat

MPO的不可逆抑制剂(IC50=630nM)；在130种酶、转运蛋白和离子通道中对MPO具有选择性（所有IC50s=>50µM）；在口服180µmol/kg剂量的PLP-αSYN转基因小鼠多系统萎缩模型中，可降低MPO表达，防止神经元丢失增加，并防止运动评分和步幅下降。An irreversible inhibitor of MPO (IC50 = 630 nM); selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all); reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy at 180 µmol/kg, p.o.分子式C11H15N3O2S分子量253.3O=C1NC(N(CCOC(C)C)C2=C1NC=C2)=S