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- 爱必信(Absin)
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- abs826262
- 2025年07月14日
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文献和实验Translocation of p47phox and Activation of NADPH Oxidase in Mononuclear Cells
subunits. Equimolar amounts of p47phox and p67phox in the cytosol combine to a form a highly basic 250 kDa protein. During activation, this complex migrates from the cytosol to the membrane where this complex combines with cytochrome b558 , which in turn
The K-562 Cell Model for Analysis of Neutrophil NADPH Oxidase Function
of the phagocytic oxidase (phox system) into the promyelocytic erythroleukemia cell line, K-562. Here, we describe a series of cloned K-562 cell lines that were retrovirally transduced for stable production of one or more essential components of the phagocytic
Assessment of the Role for Rho Family GTPases in NADPH Oxidase Activation
for microbicidal activity during phagocytosis, is activated in a manner completely dependent on Rac. Rac in the GTP-bound form directly binds to the oxidase activator p67 phox , which in turn interacts with Nox2, leading to superoxide production. Rac
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