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AJE 润色服务限时 8 折起，权威机构信任 15+ 年Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 库存：
999
- 英文名：
COX-2-IN-2
- CAS号：
134729-13-8
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 供应商：
北京索莱宝科技有限公司
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 规格：
1mg/5mg
| 规格： | 1mg | 产品价格： | ¥2110.00 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ¥5290.00 |
| CAS | 134729-13-8 |
| 英文名称 | COX-2-IN-2 |
| 分子式 | C17H12FN3O2S |
| 分子量 | 341.36 |
| 规格 | 1mg ; 5mg |
| 溶解性 | Soluble in DMSO ≥5mg/mL |
| 纯度 | ≥98% |
| 级别 | Cell Culture |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷冻运输 |
| SMILES | C(#N)C=1C=C(N(N1)C2=CC=C(F)C=C2)C3=CC=C(S(C)(=O)=O)C=C3 |
| 靶点 | COX |
| 通路 | Immunology & Inflammation |
| 背景说明 | COX-2-IN-2 是选择性的，诱导型的 COX2 抑制剂，具有抗炎和止痛活性。 |
| 生物活性 | COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.[1] |
| In Vitro | COX-2-IN-2 shows no COX-1 inhibition even at 100μM[1]. |
| In Vivo | COX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis， respectively， and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity[1]. |
| 动物实验 | Rats: Ten male Sprague Dawley rats are used per group. A suspension of 0.5% brewer‘s yeast in 0.5% methyl cellulose is injected into the right hind paw. The pain threshold us determined 3h after yeast injection. COX-2-IN-2 is given orally 2 h after yeast injection. The pain threshold in the treated rats are compared with that in the control rats[1]. |
| 激酶实验 | hCOX1 or hCOX2 is preincubated with COX2-IN-2 in 0.1 M Tris-HCl buffer containing 2 μM hematin and 5 mM L-tryptophan at 30°C for 5 min， followed by a 5 min incubation with arachidonic acid. The enzyme reaction is stopped by the addition of 1 N HCl. The PGE2 formed is extracted with EtOAc and measured by RIA[1]. |
| 数据来源文献 | [1]. Tsuji K， et al. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1，5-diarylpyrazoles and related derivatives. Chem Pharm Bull (1997)， 45(6)， 987-995. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.9295mL|14.6473mL|29.2946mL|$$|5mM|0.5859mL|2.9295mL|5.8589mL|$$|10mM|0.2929mL|1.4647mL|2.9295mL| |
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文献和实验The discovery of two isoforms of the cyclooxygenase (COX) enzyme, COX-1 and COX-2, has provided the rationale for development of selective COX-2 inhibitors as a class of safer drugs for the treatment of pain, symptoms of osteoarthritis
Cclooxygenase-2 (COX-2) Protein Expression by Western Blotting
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