Anti-MMP-14 / MT1-MMP, clone L

MMP-14 (Matrix Metalloproteinase-14), also known as MT1-MMP (Membrane-Type 1 Matrix Metalloproteinase), is an enzyme that plays a critical role in the remodeling of the extracellular matrix (ECM). It is a membrane-bound metalloproteinase that facilitates the breakdown of various ECM components, such as collagen and gelatins, by catalyzing the degradation of their peptide bonds. MMP-14 is involved in essential biological processes, including tissue development, wound healing, angiogenesis, and cell migration. It also plays a key role in pathological conditions like cancer, where its activity can promote tumor growth and metastasis by allowing cancer cells to invade surrounding tissues. The regulation of MMP-14 activity is crucial for maintaining normal tissue function and preventing excessive ECM degradation.