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- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Blebbistatin
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
674289-55-5
纯度：>98% by TLC；NMR (Conforms)
分子式：C18H16N2O2
分子量：292.34
溶剂：DMSO (45 mg/ml)
性状：Yellow solid
存储：-20°C
Activity (short version)：Non-muscle myosin II inhibitor
Function / Pharmacology：Blebbistatin is a potent, selective, reversible, cell-permeable inhibitor of non-muscle myosin II (IC50 ~4 mM).1,2 During cell division it inhibits contraction of the cleavage furrow without disrupting mitosis.1 Blocks cell blebbing (hence its name) and rapidly disrupts directed cell migration and cytokinesis in many cell types.1 It promotes neurite outgrowth3 and is neuroprotective against vincristine-induced neurotoxicity in iPSC-derived neurons4.
分子式：C18H16N2O2
分子量：292.34
溶剂：DMSO (45 mg/ml)
性状：Yellow solid
存储：-20°C
Activity (short version)：Non-muscle myosin II inhibitor
Function / Pharmacology：Blebbistatin is a potent, selective, reversible, cell-permeable inhibitor of non-muscle myosin II (IC50 ~4 mM).1,2 During cell division it inhibits contraction of the cleavage furrow without disrupting mitosis.1 Blocks cell blebbing (hence its name) and rapidly disrupts directed cell migration and cytokinesis in many cell types.1 It promotes neurite outgrowth3 and is neuroprotective against vincristine-induced neurotoxicity in iPSC-derived neurons4.
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文献和实验该产品被引用文献
674289-55-5
相关实验
Rho-kinase mutant leads to significantly increased MLC phosphorylation, membrane blebbing, and inhibition of cell polarization. This Rho-kinase-induced membrane blebbing can be inhibited by Y-27632, ML-7, and blebbistatin. Unexpectedly, overactivation
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Blebbistatin
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