- 询价
- Hello Bio
- 英国
- HB8542
- 2025年12月13日
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- 详细信息
- 技术资料
- 保存条件：
-20°C
- 英文名：
uPSEM792 hydrochloride
- 供应商：
Hello Bio
- CAS号：
2341841-08-3
- 规格：
5mg///25mg
Overview
Ultrapotent PSEM agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki values are 0.7 nM and <10 nM for PSAM4-GlyR and PSAM4-5HT3 respectively) which can be used for targeted control of brain activity in rodent and primate models.
It shows >10,000-fold agonist selectivity for PSAM4-GlyR over α-7-GlyR, α7-5HT3R and 5-HT3R.
uPSEM792 is a very weak agonist at α4β2 nAChR and shows 230-fold selectivity for PSAM4-GlyR over α4β2 nAChR.
It retains the potency of varenicline for PSAM4-GlyR with enhanced chemogenetic selectivity.
It does not act as a P-glycoprotein pump (PgP) substrate.
Uses and applications
It strongly suppresses layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices at low concentrations (ranging from 1-15 nM).
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