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- 详细信息
- 技术资料
- 保存条件:
+4°C
- 英文名:
LSL60101
- 供应商:
Hello Bio
- CAS号:
150985-54-9
- 规格:
10mg///50mg
Selective, orally available I2-imidazoline receptor ligand (Ki ratio = 286 for α2 / I2 receptors). Induces morphological/biochemical changes to astroglia, reduces apoptosis and modulates oxidative stress to show neuroprotective effects. Chronic low-dose treatment of LSL60101 also reverses cognitive deficits and impaired social behaviour in 5XFAD mice to alter Alzheimer's disease markers such as glial activation and synaptic dysfunction. Both LSL60101 treatment and LSL60101 / donepezil combination treatment decreases amyloid-β40 and amyloid-β42 levels, amyloid-β plaque number and tau hyperphosphorylation to attenuate amyloid-β pathology in 5XFAD brains.
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