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- 详细信息
- 技术资料
- 保存条件:
-20°C
- 英文名:
(Z)-4-Hydroxytamoxifen (Z-4-OHT)
- 供应商:
Hello Bio
- CAS号:
68047-06-3
- 规格:
5mg///10mg///25mg///50mg
Cell permeable, synthetic estrogen receptor ligand. Widely used in genome engineering.
CreER system:
De facto standard compound in drug-inducible manipulation of CreER recombinase. Allows external temporal control of Cre activity in vivo.
May also be used for TRAPing / in the TRAP / TRAP2 system (Targeted recombination in active populations).
CRISPR/Cas9 gene editing:
Activates an inactived Cas9 nuclease (rendered inactive by insertion of a 4-OHT dependent-intein) to reduce off-target CRISPR-mediated gene editing (once bound with 4-OHT, conditionally active Cas9s modify target genomic sites with ~25-fold higher specificity than wild-type Cas9).
Also allows tight, repeated on-off control of the nuclease activity of the ‘iCas’ Cas9 variant which shows high editing efficiency at multiple loci once bound with 4-OHT.
4-Hydroxytamoxifen (70:30 mixture of (Z):(E) isomers) also available.
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