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- Hello Bio
- 英国
- HB3690
- 2025年11月21日
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- 详细信息
- 技术资料
- 保存条件：
+4°C
- 英文名：
Aphidicolin
- 供应商：
Hello Bio
- CAS号：
38966-21-1
- 规格：
5mg///25mg
Overview
Aphidicolin is a potent DNA replication inhibitor which is often used to achieve cell synchronization.
Mechanism
Aphidicolin is a potent and specific inhibitor of B-family DNA polymerases and binds at or near the nucleotide-binding site. It prevents DNA polymerase-α from binding dNTPs without blocking the activity of DNA polymerase β or δ.
Aphidicolin inhibits DNA replication and some forms of DNA repair. During cell culture, addition of aphidicolin induces cell cycle pause at the G1/S border. DNA synthesis stops in cells that have entered S-phase, while nondividing cells are unaffected.
Uses
Aphidicolin acts synergistically with vincristine and doxorubicin. In addition to its anti-mitotic effects, it exhibits antibiotic and antiviral activities.
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