- 询价
- Hello Bio
- 英国
- HB3555
- 2025年11月21日
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- 详细信息
- 技术资料
- 保存条件：
Room temperature
- 英文名：
SB 431542
- 供应商：
Hello Bio
- CAS号：
301836-41-9
- 规格：
1mg///5mg///2x5mg///10mg///25mg///50mg///10mM (1mL in DMSO)
Potent and selective transforming growth factor β type I receptor (TGF-βRI) actvin receptor-like kinase ALK5, ALK4 and ALK7 inhibitor (IC50 = 94 nM at ALK5).
Specifically inhibits Smad2/3 activation and blocks TGF-β signal transduction.
Maintains the undifferentiated state of mouse embryonic stem cells (ESCs).
Also induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.
It additionally can be used as a 3D growth matrix component and can be used in production of organoids (e.g. brain/ blood vessel organoids).
It can also be used to replace the SOX2 factor in reprogramming protocols.
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