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- 2025年10月30日
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- 详细信息
- 技术资料
- 保存条件：
Room temperature
- 英文名：
(-)-Bicuculline methochloride
- 供应商：
Hello Bio
- CAS号：
38641-83-7
- 规格：
25mg///50mg///125mg
Methochloride salt form of (+)-bicuculline.
Prototypic, competitive GABAA receptor antagonist which displaces GABA from the agonist binding site to prevent receptor activation.
Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.
Additionally shows activity at SK calcium-activated potassium channels, nicotinic acetylcholine receptors and acetylcholinesterase.
Reversibly and competitively blocks GABAA receptor mediated currents. Widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).
Shows convulsant action and induces epilepsy.
Freebase, methiodide and methobromide salts also available.
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