- 询价
- Hello Bio
- 英国
- HB0339
- 2025年10月24日
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- 详细信息
- 技术资料
- 保存条件：
Room temperature
- 英文名：
Ifenprodil
- 供应商：
Hello Bio
- CAS号：
23210-58-4
- 规格：
10mg///25mg///50mg
Ifenprodil is a non-competitive, voltage-independent GluN2B subunit selective NMDA receptor allosteric inhibitor (IC50 = 0.15 μM).
It is selective over GluN2A (NR2A), GluN2C (NR2C) and GluN2D (NR2D) subunits (IC50 values are >30 μM).
Ifenprodil is thought to bind at the interface of the GluN1/2B NTD (ATD) (N-terminal domain).
Ifenprodil is commonly used to distinguish between GluN2B- and GluN2A- containing NMDARs in synaptic and extrasynaptic membranes.
Ifenprodil also shows use dependence in which binding of glutamate increases binding of ifenprodil and vice versa.
Shows neuroprotective effects and protects neurons against glutamate excitotoxicity in an activity-dependent manner.
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