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- Hello Bio
- 英国
- HB0338
- 2025年10月24日
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- 详细信息
- 技术资料
- 保存条件：
Room temperature (desiccate)
- 英文名：
IEM-1460
- 供应商：
Hello Bio
- CAS号：
121034-89-7
- 规格：
10mg///50mg
Competitive, selective, voltage-dependent open-channel Ca2+ permeable GluA2 (GluR2)-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 µM at GluA2-lacking and GluA2-containing AMPARs respectively).
IEM-1460 can be utilized as an indicator of the distribution of AMPA receptor subtypes among populations of brain cells.
IEM-1460 can also be used to selectively target GABAergic interneurons, as several subpopulations of these neurons express a significant proportion of GluA2-lacking Ca2+-permeable AMPARs.
Blocks synaptic excitation of fast-spiking interneurons and blocks NMDAR-mediated currents.
Also shows anticonvulsant properties.
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