DNA Synthesis Columns

SBS Genetech offers a variety of synthesis columns and standard CPG of different types and specifications. With continuous technological improvements and innovations, strict quality control, and a dedicated technical service team, we provide high-quality carriers and CPG. First Generation Universal Synthesis Columns have a large synthesis capacity and are easy to assemble. The Second Generation Synthesis Columns involve CPG sintered with ultra-high molecular weight polyethylene or high-density polyethylene, making them more efficient, faster, and economical.

SBS Genetech offers a variety of synthesis columns and standard CPG of different types and specifications. With continuous technological improvements and innovations, strict quality control, and a dedicated technical service team, we provide high-quality carriers and CPG.

First Generation Universal Synthesis Columns have a large synthesis capacity and are easy to assemble. Second Generation Synthesis Columns involve CPG sintered with ultra-high molecular weight polyethylene or high-density polyethylene, making them more efficient, faster, and economical.

First Generation Synthesis Columns 

First generation synthesis columns are filled with solid-phase carrier CPG inside the column tube, fixed by upper and lower sieve plates. They have a large synthesis capacity, are easy to assemble, and are suitable for short-chain primer synthesis.

Features of First Generation Synthesis Columns 

• Universal Linker CPG Fillers
• Optimized sieve plate flow rate and automated assembly technology
• Particularly suitable for large-scale synthesis
• Good compatibility with existing equipment and protocols

Second Generation Synthesis Columns

The second-generation universal synthesis columns combine CPG with a small filter sintering technology and universal carrier technology, integrating CPG and upper and lower sieve plates into one unit. They are compatible with mainstream commercial synthesizers.

By optimizing the height and diameter, we can reduce reagent waste and cleaner consumption, thereby lowering synthesis costs. The universal synthesis membrane is sintered from hydrophobic polyethylene base material, providing excellent hydrophobicity. This creates an ideal anhydrous environment for phosphoramidite monomers, which are highly sensitive to moisture, thus improving synthesis efficiency.

Features of Second Generation Synthesis Columns 

• High Oligo Purity: Achieves high oligo purity with a low mutation rate.
• Reduces overall synthesis cost: Significantly lowers overall synthesis costs.
• Large Synthesis Column Capacity: Allows for more reagents to be loaded due to its large capacity.