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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
详询
- 保质期:
详询
- 英文名:
Somatostatin Receptor-1 (SSTR1) Mouse Monoclonal
- 库存:
99
- 供应商:
北京孚博生物
- CAS号:
详询
- 规格:
50ug
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文献和实验Chimerization of a Monoclonal Antibody for Treating Hodgkin's Lymphoma
Conventionally, monoclonal antibodies (MAbs) are generated by fusing B cells from an immunized animal with myeloma cells from the same species (1 ). Several murine MAb have already been employed for in vivo diagnosis and therapy, including
【翻译】Development trends for monoclonal antibody cancer therapeutics
, first described in 1975 (Ref 6), involved use of mouse-derived hybridomas. However, in humans, murine mAbs were commonly (although not always) ineffective as cancer therapeutics. Studies revealed that murine candidates often had short circulating half-lives
. We isolated a variant of Herceptin, a therapeutic monoclonal antibody that binds the human epidermal growth factor receptor 2 (HER2), on the basis of its ability to simultaneously interact with vascular endothelial growth factor (VEGF). Crystallographic
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