JVM-2细胞

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 48 hours (PubMed=25315077); ~50-70 hours (DSMZ=ACC-12).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: JUM2; Note=Occasionally.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

PubMed=3093393; DOI=10.1002/ijc.2910380413

Vaz de Melo J., Brito-Babapulle V., Foroni L., Robinson D.S.F., Luzzatto L., Catovsky D.

Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement.

Int. J. Cancer 38:531-538(1986)

 

PubMed=3262465; PMCID=PMC1541467

Vaz de Melo J., Foroni L., Brito-Babapulle V., Luzzatto L., Catovsky D.

The establishment of cell lines from chronic B cell leukaemias: evidence of leukaemic origin by karyotypic abnormalities and Ig gene rearrangement.

Clin. Exp. Immunol. 73:23-28(1988)

 

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893

Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C.F.M., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.

Deletions and rearrangement of CDKN2 in lymphoid malignancy.

Blood 85:893-901(1995)

 

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

 

PubMed=16183118; DOI=10.1016/j.leukres.2005.08.016

Tucker C.A., Bebb G., Klasa R.J., Chhanabhai M., Lestou V.S., Horsman D.E., Gascoyne R.D., Wiestner A., Masin D., Bally M., Williams M.E.

Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.

Leuk. Res. 30:449-457(2006)

 

PubMed=16448697; DOI=10.1016/j.leukres.2005.11.013

Camps J., Salaverria I., Garcia M.J., Prat E., Bea S., Pole J.C.M., Hernandez L., Del Rey J., Cigudosa J.C., Bernues M., Caldas C., Colomer D., Miro R., Campo E.

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.

Leuk. Res. 30:923-934(2006)

 

PubMed=16960149; DOI=10.1182/blood-2006-06-026500

Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.

Blood 109:271-280(2007)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168

Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.

Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.

J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

 

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731

Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.

Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)