ZR-75-1细胞

ZR-75-1/ZR-75-1细胞系/ZR-75-1细胞株/ZR-75-1人乳腺导管癌细胞

Cell line name ZR-75-1

Synonyms Zr-75-1; ZR751; ZR75-1; ZR75.1; ZR75_1

Accession CVCL_0588

Resource Identification Initiative To cite this cell line use: ZR-75-1 (RRID:CVCL_0588)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: JWGray breast cancer cell line panel.

Part of: ICBP43 breast cancer cell line panel.

Part of: JFCR45 cancer cell line panel.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: 80 hours (Note=At 40th passage) (PubMed=688225); 79 hours (PubMed=24389870); ~54 hours (PBCF); 70.09 hours (JWGray panel).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: H2BK120ub ChIP-seq epigenome analysis.

Omics: H3K23ac ChIP-seq epigenome analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K36me3 ChIP-seq epigenome analysis.

Omics: H3K4me1 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: H3K79me2 ChIP-seq epigenome analysis.

Omics: H3K9ac ChIP-seq epigenome analysis.

Omics: H3K9me3 ChIP-seq epigenome analysis.

Omics: H4K8ac ChIP-seq epigenome analysis.

Omics: Glycoproteome analysis by proteomics.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Transcriptome analysis by serial analysis of gene expression (SAGE).

Anecdotal: Used in a study utilising the fruit fly's olfactory sy

PubMed=20070913; DOI=10.1186/1471-2407-10-15; PMCID=PMC2836299

Tsuji K., Kawauchi S., Saito S., Furuya T., Ikemoto K., Nakao M., Yamamoto S., Oka M., Hirano T., Sasaki K.

Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues.

BMC Cancer 10:15.1-15.10(2010)

 

PubMed=21378333

Ford C.H.J., Al-Bader M., Al-Ayadhi B., Francis I.

Reassessment of estrogen receptor expression in human breast cancer cell lines.

Anticancer Res. 31:521-527(2011)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396

Marcotte R., Brown K.R., Suarez Saiz F.J., Sayad A., Karamboulas K., Krzyzanowski P.M., Sircoulomb F., Medrano M., Fedyshyn Y., Koh J.L.-Y., van Dyk D., Fedyshyn B., Luhova M., Brito G.C., Vizeacoumar F.J., Vizeacoumar F.S., Datti A., Kasimer D., Buzina A., Mero P., Misquitta C., Normand J., Haider M., Ketela T., Wrana J.L., Rottapel R., Neel B.G., Moffat J.

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Cancer Discov. 2:172-189(2012)

 

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661

Riaz M., van Jaarsveld M.T.M., Hollestelle A., Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J.-J., Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A.C., Foekens J.A., Martens J.W.M.

miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.

Breast Cancer Res. 15:R33.1-R33.17(2013)

 

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310

Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A., Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K., McCormick F., Gray J.W.

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

Cancer Cell 24:450-465(2013)

 

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776

Prat A., Karginova O., Parker J.S., Fan C., He X.-P., Bixby L.M., Harrell J.C., Roman E., Adamo B., Troester M.A., Perou C.M.

Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.

Breast Cancer Res. Treat. 142:237-255(2013)

 

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590

Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sume V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.

Modeling precision treatment of breast cancer.

Genome Biol. 14:R110.1-R110.14(2013)

 

PubMed=24389870; DOI=10.1038/srep03576; PMCID=PMC3880960

Strauch M., Ludke A., Munch D., Laudes T., Galizia C.G., Martinelli E., Lavra L., Paolesse R., Ulivieri A., Catini A., Capuano R., Di Natale C.

More than apples and oranges -- detecting cancer with a fruit fly's antenna.

Sci. Rep. 4:3576-3576(2014)

 

PubMed=25238572; DOI=10.1021/pr500727h

Groessl M., Slany A., Bileck A., Gloessmann K., Kreutz D., Jaeger W., Pfeiler G., Gerner C.

Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts.

J. Proteome Res. 13:4773-4782(2014)

 

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

OncoImmunology 3:e954893.1-e954893.12(2014)

 

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)