Hep 3B(Hep 3B2.1-7)细胞

Hep3B/Hep3B细胞系/Hep3B细胞株/Hep3B人肝癌细胞

Cell line name Hep 3B2.1-7

Synonyms Hep 3B2_1-7; Hep 3B 2.1-7; HEP3B217; Hep 3B2; HEP-3B2; HEP3B2; Hep-3B; HEP-3B; Hep 3B; Hep3B; HEP3B

Accession CVCL_0326

Resource Identification Initiative To cite this cell line use: Hep 3B2.1-7 (RRID:CVCL_0326)

Comments Group: Patented cell line.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JFCR45 cancer cell line panel.

Part of: Liver Cancer Model Repository (LIMORE).

Part of: MD Anderson Cell Lines Project.

Part of: TCGA-110-CL cell line panel.

Registration: International Depositary Authority, American Type Culture Collection (ATCC); HB-8064.

Population: African American.

Doubling time: 28.05 hours (PubMed=31378681); ~40-50 hours (DSMZ=ACC-93).

Karyotypic information: Has lost chromosome Y.

Microsatellite instability: Stable (MSS) (Sanger).

Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Genome sequenced.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: Hep_3B1_1-7; Cosmic=2773181.

Derived from site: In situ; Liver; UBERON=UBERON_0002107.

PubMed=6288577; DOI=10.1002/ijc.2910300106

Simon D., Aden D.P., Knowles B.B.

Chromosomes of human hepatoma cell lines.

Int. J. Cancer 30:27-33(1982)

 

Patent=US4393133

Knowles B.B., Aden D.P.

Human hepatoma derived cell line, process for preparation thereof, and uses therefor.

Patent number US4393133, 12-Jul-1983

 

PubMed=3023526; DOI=10.1099/0022-1317-67-11-2315

Aspinall S., Alexander J.J., Bos P.

Comparative expression of hepatitis B virus antigens in several cell model systems.

J. Gen. Virol. 67:2315-2323(1986)

 

DOI=10.1007/978-4-431-68349-0_4

Alexander J.J.

Human hepatoma cell lines.

(In book chapter) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo; Japan (1987)

 

PubMed=2439335; DOI=10.1111/j.1432-1033.1987.tb11497.x

Vincent C., Marceau M., Blangarin P., Bouic P., Madjar J.-J., Revillard J.-P.

Purification of alpha 1-microglobulin produced by human hepatoma cell lines. Biochemical characterization and comparison with alpha 1-microglobulin synthesized by human hepatocytes.

Eur. J. Biochem. 165:699-704(1987)

 

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613

Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E., Ponchel F., Yakicier C., Ji J.-W., Ozturk M.

Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.

FASEB J. 7:1407-1413(1993)

 

PubMed=8389256; DOI=10.1093/carcin/14.5.987

Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T., Harris C.C.

p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.

Carcinogenesis 14:987-992(1993)

 

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163

Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.

Mutations and altered expression of p16INK4 in human cancer.

Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

 

PubMed=8050184; DOI=10.1111/j.1365-2249.1994.tb06089.x; PMCID=PMC1534706

Wadee A.A., Paterson A., Coplan K.A., Reddy S.G.

HLA expression in hepatocellular carcinoma cell lines.

Clin. Exp. Immunol. 97:328-333(1994)

 

PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A

Tsuboi S., Nagamori S., Miyazaki M., Mihara K., Fukaya K.-i., Teruya K., Kosaka T., Tsuji T., Namba M.

Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.

J. Med. Virol. 48:133-140(1996)

 

DOI=10.11418/jtca1981.16.3_173

Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ohashi R., Namba M.

The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.

Tissue Cult. Res. Commun. 16:173-178(1997)

 

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D

Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Screening the p53 status of human cell lines using a yeast functional assay.

Mol. Carcinog. 19:243-253(1997)