H9c2(2-1)细胞

H9C2(2-1) /H9C2(2-1) 细胞系/H9C2(2-1) 细胞株/H9C2(2-1) 大鼠心肌细胞

Cell line name    H9c2(2-1)
Synonyms    H9c2 (2-1); H9c2; H9C2
Accession    CVCL_0286
Resource Identification Initiative    To cite this cell line use: H9c2(2-1) (RRID:CVCL_0286)
Comments    Derived from site: In situ; Embryonic heart, cardiac muscle; UBERON=UBERON_0003084+UBERON_0001133.
Species of origin    Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: BDIX; RS=RS:0000091.
Hierarchy    Children:
CVCL_B0FS (H9c2 Trpm4 KO)    CVCL_C8V4 (H9C2(2-1)-Luc)    CVCL_XE64 (H9C2(2-1)-Luc2-tdT)
CVCL_XE65 (H9C2(2-1)-mCherry)    CVCL_XE66 (H9C2(2-1)-tdT)    CVCL_E1JX (HyCyte H9c2(2-1) KO-rCpt1a)
CVCL_E1JY (HyCyte H9c2(2-1) KO-rMapk1)    CVCL_D8GF (Ubigene H9c2(2-1) Ankrd23 KO)    CVCL_D8GG (Ubigene H9c2(2-1) Dsp KO)
CVCL_D8GH (Ubigene H9c2(2-1) Fgfr1 KO)    CVCL_D8GI (Ubigene H9c2(2-1) Glp1r KO)    CVCL_D8GJ (Ubigene H9c2(2-1) Hif1an KO)
CVCL_D8GK (Ubigene H9c2(2-1) Otub1 KO)    CVCL_D8GL (Ubigene H9c2(2-1) Piezo2 KO)    CVCL_D8GM (Ubigene H9c2(2-1) Scaf1 KO)
CVCL_D8GN (Ubigene H9c2(2-1) Senp1 KO)    CVCL_D8GP (Ubigene H9c2(2-1) Tmem175 KO)    CVCL_D8GQ (Ubigene H9c2(2-1) Tpm1 KO)
Sex of cell    Sex unspecified
Age at sampling    Embryo
Category    Spontaneously immortalized cell line
Publications    
PubMed=943302; DOI=10.1016/0014-4827(76)90447-X
Kimes B.W., Brandt B.L.
Properties of a clonal muscle cell line from rat heart.
Exp. Cell Res. 98:367-381(1976)

PubMed=1683272; DOI=10.1161/01.RES.69.6.1476
Hescheler J., Meyer R., Plant S., Krautwurst D., Rosenthal W., Schultz G.
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.
Circ. Res. 69:1476-1486(1991)

PubMed=17662623; DOI=10.1016/j.vascn.2007.06.001
Zordoky B.N.M., El-Kadi A.O.S.
H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart.
J. Pharmacol. Toxicol. Methods 56:317-322(2007)

PubMed=21082279; DOI=10.1007/s11626-010-9368-1
Watkins S.J., Borthwick G.M., Arthur H.M.
The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro.
In Vitro Cell. Dev. Biol. Anim. 47:125-131(2011)