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- 英文名：
GC-Globulin, Human Plasma, Mixed Type (Vitamin D Binding Protein)
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An alpha 2 glycoprotein composed of a single polypeptide chain and present in plasma at levels of 20-55 mg/100 ml. It functions in the binding and transport of vitamin D and may also play an important role in actin homeostatis since it has been shown to bind monomeric actin with high affinity. GC-globulin also binds membranes of both circulating B and T lymphocytes. Clinically, concentrations are reduced in patients with severe liver diseases. GC-globulin may also play an important role in the mechanism of the osteomalacia that occurs with Itai-Itai disease.
一种α2糖蛋白，由一条多肽链组成，在血浆中的含量为20 - 55毫克/100毫升。它的功能是结合并运输维生素D，并且由于已证实它能高亲和力地结合单体肌动蛋白，所以可能在肌动蛋白稳态中也发挥重要作用。维生素D结合蛋白（GC球蛋白）还能结合循环中的B淋巴细胞和T淋巴细胞的细胞膜。临床上，严重肝病患者体内该蛋白的浓度会降低。GC球蛋白在痛痛病引发的骨软化症发病机制中可能也起到重要作用 。
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文献和实验
are not as important, as you are looking for a relatively small number of differences and so can devote more time to the identification of each protein.2D electrophoresis is performed in two steps(1) Isoelectric focusing (IEF) (First dimension electrophoresis): is used
ANTIBODY BINDING TO PROTEIN A AND PROTEIN G
. A physicochemical study f protein G, a molecule with unique immunoglobulin G-binding properties. J. Biol. Chem. 261:10240-10247. Harlow, E. and Lane, D. 1988. Antibodies. A laboratory manual. Cold Spring Harbor Laboratory. Kronvall, G., Seal, U. S
are not as important, as you are looking for a relatively small number of differences and so can devote more time to the identification of each protein.2D electrophoresis is performed in two steps(1) Isoelectric focusing (IEF) (First dimension electrophoresis
