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Anti-APP-C31 | Caspase 3 cleav

ed APP, C terminal fragment
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  • 询价
  • Agrisera
  • Sweden
  • AS21 4570
  • 2026年01月07日
  • ELISA (ELISA), Immunolocalisation (IL), Western blot (WB)
  • Rabbit
  • Human, Mouse, Rat
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide corresponding to the N-terminal of human caspase 3-generated APP C-terminal 31 amino acids (aa 665-670) UniProt: P05067

    • 形态

      Serum. Contains 0.05% sodium azide.

    • 保存条件

      Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

    • 适应物种

      Human, Mouse, Rat

    • 供应商

      Agrisera

    • 宿主

      Rabbit

    • 应用范围

      ELISA (ELISA), Immunolocalisation (IL), Western blot (WB)

    • 靶点

      Anti-APP-C31 | Caspase 3 cleaved APP, C terminal fragment

    • 抗体英文名

      Anti-APP-C31 | Caspase 3 cleaved APP, C terminal fragment

    • 抗体名

      Anti-APP-C31 | Caspase 3 cleaved APP, C terminal fragment

    • 规格

      100 µl

    The Alzheimer Amyloid Precursor Protein (APP) is a transmembrane protein whose abnormal processing is associated with the pathogenesis of Alzheimer’s disease. APP695 lacking the protease inhibitor domain is the predominant form in neuronal tissues. APP695 is cleaved by caspases into the 664-residue amino (N)-terminal fragment that lacks the carboxyl C-terminal 31-residues (APPC31) and the 31-residues C-terminal fragment (APP-C31). Both fragments might be potent inducers of neuronal apoptosis. An antibody (named ACT1) against the N-terminus of caspase 3-generated APP C-terminal 31 aa of human APP695 (APP-C31 ) was raised in rabbit.

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    图标文献和实验
    该产品被引用文献
    Nishimura et al. (2002) Cell death induced by a caspase-cleaved transmembrane fragment of the Alzheimer amyloid precursor protein. Cell Death Differ. 2002 Feb;9(2):199-208. doi: 10.1038/sj.cdd.4400931. PMID: 11840170.
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    Anti-APP-C31 | Caspase 3 cleaved APP, C terminal fragment
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