Purified recombinant protein o
f Human glycogen synthase kinase 3 beta (GSK3B), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug- ￥4020
- OriGene
- TP710339
- 2026年05月29日
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Description：Purified recombinant protein of Human glycogen synthase kinase 3 beta (GSK3B), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug
Accn：NM_002093
Unipro ID：P49841
Synonyms
Species：Human
Amount：20 ug
Delivery time：现货
Expression sequence：A DNA sequence from TrueORF clone, [RC200468], encoding human full-length GSK3B
Tags：C-DDK
PredictedMW：47.9 kDa
Buffer：50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
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Background：The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
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文献和实验and regulation of complex assembly. Science. 272 , 1023–1026. 9. Yamamoto H, Kishida S, Kishida M, Ikeda S,Takada S, Kikuchi A. (1999) Phosphorylationof axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
and beta isoforms in patients with NIDDM. Diabetologia 40, 940–946. 3. Shaw, P. C., Davies, A. F., Lau, K. F., Garcia-Barcelo, M., Waye, M. M., Lovestone, S., et al. (1998) Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha
Introduction of human 14-3-3 proteins
which was found recently to be a major protein-tyrosine kinase (PTK)substrate,and to interact with several signaling molecules including PI3-K,in T lymphocytes.The association between 14-3-3tau and Cbl was detected both in vitro and in intact T cells and,in contrast to Raf
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