- 询价
- 基于PhIP-seq技术平台，抗码芯瑞建立了过敏原抗原库。我们收集整理了来自五个权威过敏原信息的公开数据库，同时补充了Uniprot数据库中注释为过敏的蛋白，共涵盖856个物种， 5,436个过敏原蛋白，对应设计了37,263条肽段，建立了噬菌体展示过敏原肽库。
- 中国上海
- 2025年12月29日
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 提供商：
ABCODE
- 服务名称：
过敏原抗体谱研究
过敏原抗体谱研究
基于PhIP-Seq技术平台，抗码芯瑞建立了过敏原抗原库。我们收集整理了来自五个权威过敏原信息的公开数据库，同时补充了Uniprot数据库中注释为过敏的蛋白，共涵盖856个物种， 5,436个过敏原蛋白，对应设计了37,263条肽段，建立了噬菌体展示过敏原肽库。
过敏原抗原库(AbCode_Allergen Lib)信息。A. 过敏原来源物种示意图；B. 所参考的主要过敏原数据库；C. 每个蛋白的多肽设计规则，即每个蛋白切割为多条50%重叠、长度为56 aa的肽段并展示于噬菌体表面。
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验[1] Larman, H.B.; Zhao, Z.; Laserson, U.; Li, M.Z.; Ciccia, A.; Gakidis, M.A.; Church, G.M.; Kesari, S.; Leproust, E.M.; Solimini, N.L.;et al. Autoantigen discovery with a synthetic human peptidome. Nat. Biotechnol. 2011, 29, 535–541.
[2] Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun. 2013 Jun;43:1-9.
[3] Xu, G. J., Kula, T., Xu, Q., Li, M. Z., Vernon, S. D., Ndung'u, T., et al. (2015). Comprehensive serological profiling of human populations using a synthetic human virome. Science, 348(6239): aaa0698.
[4] Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJ. Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7526-E7534.
[5] Mandel-Brehm C, Dubey D, Kryzer TJ, O'Donovan BD, Tran B, Vazquez SE, Sample HA, Zorn KC, Khan LM, Bledsoe IO, McKeon A, Pleasure SJ, Lennon VA, DeRisi JL, Wilson MR, Pittock SJ. Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. N Engl J Med. 2019 Jul 4;381(1):47-54.
[6] Liu J, Tang W, Budhu A, Forgues M, Hernandez MO, Candia J, Kim Y, Bowman ED, Ambs S, Zhao Y, Tran B, Wu X, Koh C, Surana P, Liang TJ, Guarnera M, Mann D, Rajaure M, Greten TF, Wang Z, Yu H, Wang XW. A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma. Cell. 2020 Jul 23;182(2):317-328.e10.
[7] Monaco DR, Sie BM, Nirschl TR, Knight AC, Sampson HA, Nowak-Wegrzyn A, Wood RA, Hamilton RG, Frischmeyer-Guerrerio PA, Larman HB. Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes. Nat Commun. 2021 Jan 22;12(1):379.
[8] Dubey D, Beecher G, Hammami MB, Knight AM, Liewluck T, Triplett J, Datta A, Dasari S, Zhang Y, Roforth MM, Jerde CR, Murphy SJ, Litchy WJ, Amato A, Lennon VA, McKeon A, Mills JR, Pittock SJ, Milone M. Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults. JAMA Neurol. 2022 Aug 1;79(8):808-816.
[9] Andreu-Sánchez S, Bourgonje AR, Vogl T, Kurilshikov A, Leviatan S, Ruiz-Moreno AJ, Hu S, Sinha T, Vich Vila A, Klompus S, Kalka IN, de Leeuw K, Arends S, Jonkers I, Withoff S; Lifelines Cohort Study; Brouwer E, Weinberger A, Wijmenga C, Segal E, Weersma RK, Fu J, Zhernakova A. Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire. Immunity. 2023 Jun 13;56(6):1376-1392.e8.
[10] Shrock EL, Timms RT, Kula T, Mena EL, West AP Jr, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ. Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Science. 2023 Apr 7;380(6640):eadc9498.
