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- 文献和实验
- 技术资料
- 免疫原:
inquire
- 亚型:
Rabbit/Human Fc chimeric IgG1
- 形态:
Powder
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 保质期:
12个月
- 级别:
Research use only
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 宿主:
Rabbit
- 应用范围:
Flow Cyt
- 浓度:
详见COA
- 靶点:
CD6
- 抗体英文名:
Anti-CD6 antibody(1G6); IgG1 Chimeric mAb
- 抗体名:
Anti-CD6 antibody(1G6); IgG1 Chimeric mAb
- 规格:
10μg
| 产品类型 | Monoclonal antibodies |
|---|---|
| 靶点 | CD6 |
| Uniprot ID | P30203 |
| 背景 | This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| 克隆ID | 1G6 |
| 货期 | In Stock |
| 产品英文名称 | Anti-CD6 antibody(1G6); IgG1 Chimeric mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | TP120 |
| 应用 | Flow Cyt |
| 克隆类型 | Monoclonal |
| 偶联情况 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 宿主种属 | Rabbit |
| IgG亚型 | Rabbit/Human Fc chimeric IgG1 |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1/100 |
| 应用范围 | Research use only |

Figure 1. Flow cytometry analysis with Anti-CD6 (1G6) mAb on HEK293 cells transfected with human CD6 (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).

Figure 2. Flow cytometry analysis of antigen binding of anti-human CD6 mAb(DMC101005). (A) DMC101005 does not bind to CHO-S cells that do not express CD6. (B) A clear peak shift of DMC101005 was seen compared to the control when incubated with CD6-expressing HUT78 cells, indicating strong binding of DMC101005 to CD6. Antibodies were incubated at 5 μg/mL.
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抗体是机体免疫系统的重要效应分子,其结构多样,可特异识别抗原,并且自身之间可相互识别。抗体在现代医学中起着重要的作用,被广泛地应用于实验室研究、疾病的诊断与治疗。抗体技术发展经历了四个阶段:第一代:杂交瘤单克隆抗体技术;第二代:嵌合抗体和人源化改造单克隆抗体技术;第三代:全人重组抗体技术;第四代:天然全人重组抗体技术。 过去由于均质性的全人重组抗体通过传统的制备方法很难大量获得,限制了抗体的大规模临床应用。而 90 年代初发展起来的噬菌体抗体库技术为制备全人重组单抗提供了可能。噬菌体抗体将基因
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