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- 详细信息
- 文献和实验
- 技术资料
- 库存:
100⁺瓶
- 英文名:
apo-transferrin Human
- CAS号:
11096-37-0
- 保质期:
1年
- 供应商:
上海睿安生物13611631389
- 保存条件:
-20°C
- 规格:
1g/瓶
Sigma货号T8158人转铁蛋白13611631389上海睿安生物
100mg目录价格¥1564.06元
1g目录价格¥9,509.18元
说明
一般描述:转铁蛋白是具有分支糖链的糖蛋白,多肽链中具有两个铁离子结合位点。
应用
人转铁蛋白已用于:
- 与IgG一起孵育人近端肾小管细胞(HKC)-8个细胞,检验白蛋白特异性
- 用作人糖原细胞培养的含血清/无人甲状腺细胞培养液的补充剂
- 用作开发凝胶肼解法的靶糖蛋白
生化/生理作用
转铁蛋白介导铁从血浆向细胞的运输。与铁结合的转铁蛋白具有三种形式:单铁A/B转铁蛋白和二铁转铁蛋白。转铁蛋白可与特定的细胞表面受体结合,通过内吞作用内化。进入细胞后,铁被释放到细胞中,无铁转铁蛋白(也称为脱铁转铁蛋白)则通过胞吐作用释放到细胞外,而不会被降解。目前确知转铁蛋白可将铁以生理学安全有效的形式递送至细胞。
其他说明:部分铁饱和
制备说明:60℃热处理10小时。
分析说明:通过琼脂糖电泳纯化。

同行评审论文(文献)
Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function.
Martijn F Hoes et al.
European journal of heart failure, 20(5), 910-919 (2018-02-28)
Iron deficiency is common in patients with heart failure and associated with a poor cardiac function and higher mortality. How iron deficiency impairs cardiac function on a cellular level in the human setting is unknown. This study aims to determine
Cells: Molecules and Mechanisms, 174-174 (2009)
Non-transferrin bound iron: a key role in iron overload and iron toxicity
Brissot P, et al.
Biochim. Biophys. Acta Gen. Subj., 1820(3), 403-410 (2012)
Detection of N-glycans on small amounts of glycoproteins in tissue samples and sodium dodecyl sulfate-polyacrylamide gels
Yoshimura T, et al.
Analytical Biochemistry, 423(2), 253-260 (2012)
pH and the recycling of transferrin during receptor-mediated endocytosis.
A Dautry-Varsat et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(8), 2258-2262 (1983-04-01)
At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to



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文献和实验该产品被引用文献
Sigma货号T8158人转铁蛋白13611631389上海睿安生物
100mg目录价格¥1564.06元
1g目录价格¥9,509.18元
说明
一般描述:转铁蛋白是具有分支糖链的糖蛋白,多肽链中具有两个铁离子结合位点。
应用
人转铁蛋白已用于:
- 与IgG一起孵育人近端肾小管细胞(HKC)-8个细胞,检验白蛋白特异性
- 用作人糖原细胞培养的含血清/无人甲状腺细胞培养液的补充剂
- 用作开发凝胶肼解法的靶糖蛋白
生化/生理作用
转铁蛋白介导铁从血浆向细胞的运输。与铁结合的转铁蛋白具有三种形式:单铁A/B转铁蛋白和二铁转铁蛋白。转铁蛋白可与特定的细胞表面受体结合,通过内吞作用内化。进入细胞后,铁被释放到细胞中,无铁转铁蛋白(也称为脱铁转铁蛋白)则通过胞吐作用释放到细胞外,而不会被降解。目前确知转铁蛋白可将铁以生理学安全有效的形式递送至细胞。
其他说明:部分铁饱和
制备说明:60℃热处理10小时。
分析说明:通过琼脂糖电泳纯化。

同行评审论文(文献)
Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function.
Martijn F Hoes et al.
European journal of heart failure, 20(5), 910-919 (2018-02-28)
Iron deficiency is common in patients with heart failure and associated with a poor cardiac function and higher mortality. How iron deficiency impairs cardiac function on a cellular level in the human setting is unknown. This study aims to determine
Cells: Molecules and Mechanisms, 174-174 (2009)
Non-transferrin bound iron: a key role in iron overload and iron toxicity
Brissot P, et al.
Biochim. Biophys. Acta Gen. Subj., 1820(3), 403-410 (2012)
Detection of N-glycans on small amounts of glycoproteins in tissue samples and sodium dodecyl sulfate-polyacrylamide gels
Yoshimura T, et al.
Analytical Biochemistry, 423(2), 253-260 (2012)
pH and the recycling of transferrin during receptor-mediated endocytosis.
A Dautry-Varsat et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(8), 2258-2262 (1983-04-01)
At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to



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Sigma货号T8158人转铁蛋白13611631389上海睿安生物
¥9509.18











