CEM/C1

CEM/C1/CEM/C1细胞系/CEM/C1细胞株/CEM/C1人急性淋巴细胞白血病细胞

Cell line name CEM/C1

Synonyms CCRF-CEM C1; CEM-C1; CEM.C1; CEMC1

Accession CVCL_3496

Resource Identification Initiative To cite this cell line use: CEM/C1 (RRID:CVCL_3496)

Comments Population: Caucasian.

Doubling time: ~26 hours (ATCC=CRL-2265).

Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).

Omics: SNP array analysis.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Cell type: T-cell; CL=CL_0000084.

file Source(s): ATCC=CRL-2265; IZSLER=BS TCL 160

 

Markers:

Amelogenin X

CSF1PO 11

D5S818 12,13

D7S820 9,12

D13S317 9,10,12 (ATCC=CRL-2265)

10,12 (IZSLER=BS TCL 160)

D16S539 10,13

D21S11 30,33.2,34.2

TH01 6,7

TPOX 8

vWA 18,19

 

Run an STR similarity search on this cell line

Publications

PubMed=7579731

Kapoor R., Slade D.L., Fujimori A., Pommier Y., Harker W.G.

Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin.

Oncol. Res. 7:83-95(1995)

 

PubMed=8895760

Geley S., Hartmann B.L., Hala M., Strasser-Wozak E.M.C., Kapelari K., Kofler R.

Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.

Cancer Res. 56:5033-5038(1996)

 

PubMed=12068308; DOI=10.1038/nature00766

Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Mutations of the BRAF gene in human cancer.

Nature 417:949-954(2002)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)