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hCMEC/D3/hCMEC/D3细胞系/hCMEC/D3细胞株/hCMEC/D3永生化人脑微血管内皮细胞
Cell line name hCMEC/D3
Synonyms HCMEC/D3; CMEC/D3; human Cortical Microvessels Endothelial Cells/D3
Accession CVCL_U985
Resource Identification Initiative To cite this cell line use: hCMEC/D3 (RRID:CVCL_U985)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-3308.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11730; TERT.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Deep quantitative membrane proteome analysis.
Omics: Secretome proteome analysis.
Derived from site: In situ; Brain, temporal lobe, blood microvessel; UBERON=UBERON_0001871+UBERON_8410081.
Cell type: Endothelial cell; CL=CL_0000115.
PubMed=16141364; DOI=10.1096/fj.04-3458fje
Weksler B.B., Subileau E.-A., Perriere N., Charneau P., Holloway K.A., Leveque M., Tricoire-Leignel H., Nicotra A., Bourdoulous S., Turowski P., Male D.K., Roux F., Greenwood J., Romero I.A., Couraud P.-O.
Blood-brain barrier-specific properties of a human adult brain endothelial cell line.
FASEB J. 19:1872-1874(2005)
Patent=US8084254
Couraud P.-O., Romero I.A., Weksler B.B.
Human blood brain barrier model.
Patent number US8084254, 27-Dec-2011
PubMed=23531482; DOI=10.1186/2045-8118-10-16; PMCID=PMC3623852
Weksler B.B., Romero I.A., Couraud P.-O.
The hCMEC/D3 cell line as a model of the human blood brain barrier.
Fluids Barriers CNS 10:16.1-16.10(2013)
PubMed=26718731; DOI=10.1016/j.jprot.2015.12.011
Llombart V., Garcia-Berrocoso T., Bech-Serra J.J., Simats A., Bustamante A., Giralt D., Reverter-Branchat G., Canals F., Hernandez-Guillamon M., Montaner J.
Characterization of secretomes from a human blood brain barrier endothelial cells in-vitro model after ischemia by stable isotope labeling with aminoacids in cell culture (SILAC).
J. Proteomics 133:100-112(2016)
PubMed=30983357; DOI=10.1021/acs.molpharmaceut.9b00114
Masuda T., Hoshiyama T., Uemura T., Hirayama-Kurogi M., Ogata S., Furukawa A., Couraud P.-O., Furihata T., Ito S., Ohtsuki S.
Large-scale quantitative comparison of plasma transmembrane proteins between two human blood-brain barrier model cell lines, hCMEC/D3 and HBMEC/cibeta.
Mol. Pharm. 16:2162-2171(2019)
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文献和实验*发表【中文论文】请标注：由上海酶研生物科技有限公司提供；
*发表【英文论文】请标注：From Shanghai EK-Bioscience Biotechnology Co., Ltd.
