A2058

A2058/A2058细胞系/A2058细胞株/A2058人黑色素瘤细胞

Cell line name A2058

Synonyms A 2058; A-2058

Accession CVCL_1059

Resource Identification Initiative To cite this cell line use: A2058 (RRID:CVCL_1059)

Comments Part of: BRAF genetic alteration cell panel (ATCC TCP-1032).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11147.

Population: Caucasian.

Doubling time: 27 hours (PubMed=25984343).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: A2658; CGH-DB=9291-4.

Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

PubMed=17308088; DOI=10.1158/0008-5472.CAN-06-3311

Shields J.M., Thomas N.E., Cregger M., Berger A.J., Leslie M., Torrice C., Hao H.-L., Penland S., Arbiser J.L., Scott G.A., Zhou T., Bar-Eli M., Bear J.E., Der C.J., Kaufmann W.K., Rimm D.L., Sharpless N.E.

Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.

Cancer Res. 67:1502-1512(2007)

 

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x

Johansson P., Pavey S., Hayward N.K.

Confirmation of a BRAF mutation-associated gene expression signature in melanoma.

Pigment Cell Res. 20:216-221(2007)

 

PubMed=19147755; DOI=10.1158/1078-0432.CCR-08-1916

Augustine C.K., Yoo J.S., Potti A., Yoshimoto Y., Zipfel P.A., Friedman H.S., Nevins J.R., Ali-Osman F., Tyler D.S.

Genomic and molecular profiling predicts response to temozolomide in melanoma.

Clin. Cancer Res. 15:502-510(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676

Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V., Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M., Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.

A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.

Mol. Cancer Ther. 11:888-897(2012)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)