RD

RD/RD细胞系/RD细胞株/RD人恶性胚胎横纹肌瘤细胞

Cell line name RD

Synonyms R D; RD-2; RD 2; 130T; 130-T; 130 T; TE-32; TE 32; TE32; TE 32.T; Te 32.T

Accession CVCL_1649

Secondary accession CVCL_S332

Resource Identification Initiative To cite this cell line use: RD (RRID:CVCL_1649)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).

Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.

Population: Caucasian.

Doubling time: 23 hours (PubMed=20922763).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Cell surface proteome.

Omics: Exosome proteome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Pelvis, muscle; UBERON=UBERON_0001325.

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=2216456

Stratton M.R., Moss S., Warren W., Patterson H., Clark J., Fisher C., Fletcher C.D.M., Ball A., Thomas M., Gusterson B.A., Cooper C.S.

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.

Oncogene 5:1297-1301(1990)

 

PubMed=2302710

Ozkaynak M.F., Nolta J., Parkman R.

In vitro purging of human rhabdomyosarcoma cells using 4-hydroperoxycyclophosphamide.

Cancer Res. 50:1455-1458(1990)

 

CLPUB00569

Dickman P.S., Tsokos M.G., Triche T.J.

Biology of rhabdomyosarcoma: cell culture, xenografts, and animal models.

(In book chapter) Rhabdomyosarcoma and related tumors in children and adolescents; Maurer H.M., Ruymann F.B., Pochedly C.E. (eds.); pp.49-88; CRC Press; Boca Raton; USA (1991)

 

PubMed=1917385

Lollini P.-L., De Giovanni C., Landuzzi L., Nicoletti G., Scotlandi K., Nanni P.

Reduced metastatic ability of in vitro differentiated human rhabdomyosarcoma cells.

Invasion Metastasis 11:116-124(1991)

 

PubMed=8275086; DOI=10.1038/ng1193-230

Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S., Rauscher F.J. 3rd, Emanuel B.S., Rovera G., Barr F.G.

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.

Nat. Genet. 5:230-235(1993)

 

PubMed=8383879; DOI=10.1126/science.8383879

Tapscott S.J., Thayer M.J., Weintraub H.M.

Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis.

Science 259:1450-1453(1993)

 

PubMed=10899454; DOI=10.1016/S0960-8966(00)00096-1

Vergani L., Prescott A.R., Holt I.J.

Rhabdomyosarcoma rho(0) cells: isolation and characterization of a mitochondrial DNA depleted cell line with 'muscle-like' properties.

Neuromuscul. Disord. 10:454-459(2000)

 

PubMed=12068308; DOI=10.1038/nature00766

Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Mutations of the BRAF gene in human cancer.

Nature 417:949-954(2002)

 

PubMed=16518851; DOI=10.1002/gcc.20322

Chen Y.-Y., Takita J., Hiwatari M., Igarashi T., Hanada R., Kikuchi A., Hongo T., Taki T., Ogasawara M., Shimada A., Hayashi Y.

Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.

Genes Chromosomes Cancer 45:583-591(2006)