SK-N-AS

SK-N-AS/SK-N-AS细胞系/SK-N-AS细胞株/SK-N-AS人脑神经母细胞瘤细胞

Cell line name SK-N-AS

Synonyms SKN-AS; SKNAS

Accession CVCL_1700

Resource Identification Initiative To cite this cell line use: SK-N-AS (RRID:CVCL_1700)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

From: Memorial Sloan Kettering Cancer Center; New York; USA.

Population: Caucasian.

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: Chromatin accessibility by ATAC-seq.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep phosphoproteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: H3K27ac ChIP-seq epigenome analysis.

Omics: H3K27me3 ChIP-seq epigenome analysis.

Omics: H3K4me1 ChIP-seq epigenome analysis.

Omics: H3K4me3 ChIP-seq epigenome analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: SK-NA-S; PubMed=15892104.

Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.

PubMed=11550280; DOI=10.1002/gcc.1174

Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B., Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.

Genes Chromosomes Cancer 32:126-135(2001)

 

PubMed=12068308; DOI=10.1038/nature00766

Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Mutations of the BRAF gene in human cancer.

Nature 417:949-954(2002)

 

PubMed=12702577

Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.

PPM1D is a potential target for 17q gain in neuroblastoma.

Cancer Res. 63:1876-1883(2003)

 

PubMed=15892104; DOI=10.1002/gcc.20198

Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K.A., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Genes Chromosomes Cancer 43:390-403(2005)

 

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846

Dam V., Morgan B.T., Mazanek P., Hogarty M.D.

Mutations in PIK3CA are infrequent in neuroblastoma.

BMC Cancer 6:177.1-177.10(2006)

 

PubMed=17506115; DOI=10.1002/nbm.1181

Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A., Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.

1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.

NMR Biomed. 20:692-700(2007)

 

PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026

Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M., Hayashi Y.

Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.

J. Pediatr. Surg. 42:2040-2045(2007)

 

PubMed=18534018; DOI=10.1186/1476-4598-7-50; PMCID=PMC2442611

Combaret V., Boyault S., Iacono I., Brejon S., Rousseau R., Puisieux A.

Effect of bortezomib on human neuroblastoma: analysis of molecular mechanisms involved in cytotoxicity.

Mol. Cancer 7:50.1-50.12(2008)

 

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043

Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.

Identification of ALK as a major familial neuroblastoma predisposition gene.

Nature 455:930-935(2008)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027

Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Cell 142:218-229(2010)

 

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132

Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

Int. J. Cancer 131:1556-1568(2012)