BxPC-3

【BxPC-3】BxPC-3细胞/BxPC-3细胞/BxPC-3人原位胰腺腺癌细胞Cell line name BxPC-3

Synonyms BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3

Accession CVCL_0186

Resource Identification Initiative To cite this cell line use: BxPC-3 (RRID:CVCL_0186)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: 48-60 hours (PubMed=3754176); 48 hours (PubMed=25984343); ~48 hours (DSMZ=ACC-760).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Metabolome analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Caution: Additional TP53 mutation in c.793C>T indicated incorrectly in PubMed=1630814.

Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.

PubMed=8026879; DOI=10.1002/ijc.2910580207

Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.

Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.

Int. J. Cancer 58:185-191(1994)

 

PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7

Simon B., Weinel R., Hohne M., Watz J., Schmidt J., Kortner G., Arnold R.

Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma.

Gastroenterology 106:1645-1651(1994)

 

PubMed=8286197; DOI=10.1038/bjc.1994.24; PMCID=PMC1968784

Lohr J.-M., Trautmann B., Gottler M., Peters S., Zauner I., Maillet B., Kloppel G.

Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins.

Br. J. Cancer 69:144-151(1994)

 

PubMed=21607521; DOI=10.3892/or.1.6.1223

Iguchi H., Morita R., Yasuda D., Takayanagi R., Ikeda Y., Takada Y., Shimazoe T., Nawata H., Kono A.

Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.

Oncol. Rep. 1:1223-1227(1994)

 

PubMed=9788440; DOI=10.1038/sj.onc.1202118

Villanueva A., Garcia C., Paules Blazquez A.B., Vicente M., Megias M., Reyes G., de Villalonga P., Agell N., Lluis F., Bachs O., Capella G.

Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

Oncogene 17:1969-1978(1998)

 

PubMed=10027410; DOI=10.1016/S0002-9440(10)65298-4; PMCID=PMC1850008

Ghadimi B.M., Schrock E., Walker R.L., Wangsa D., Jauho A., Meltzer P.S., Ried T.

Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.

Am. J. Pathol. 154:525-536(1999)

 

PubMed=10408907; DOI=10.1016/S0304-3835(98)00380-2

Bartsch D.K., Barth P., Bastian D., Ramaswamy A., Gerdes B., Chaloupka B., Deiss Y., Simon B., Schudy A.

Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas.

Cancer Lett. 139:43-49(1999)

 

PubMed=11115575; DOI=10.3892/or.8.1.89

Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.

Oncol. Rep. 8:89-92(2001)

 

PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C

Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M., Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.

Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.

Int. J. Cancer 91:350-358(2001)

 

PubMed=12692724; DOI=10.1007/s00428-003-0784-4

Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.

A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.

Virchows Arch. 442:444-452(2003)

 

PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159

Heidenblad M., Schoenmakers E.F.P.M., Jonson T., Gorunova L., Veltman J.A., van Kessel A.G., Hoglund M.

Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines.

Cancer Res. 64:3052-3059(2004)

 

PubMed=15367885; DOI=10.1097/00006676-200410000-00004

Loukopoulos P., Kanetaka K., Takamura M., Shibata T., Sakamoto M., Hirohashi S.

Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.

Pancreas 29:193-203(2004)

 

PubMed=15688027; DOI=10.1038/sj.onc.1208383

Heidenblad M., Lindgren D., Veltman J.A., Jonson T., Mahlamaki E.H., Gorunova L., van Kessel A.G., Schoenmakers E.F.P.M., Hoglund M.

Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications.

Oncogene 24:1794-1801(2005)

 

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721

Calhoun E.S., Hucl T., Gallmeier E., West K.M., Arking D.E., Maitra A., Iacobuzio-Donahue C.A., Chakravarti A., Hruban R.H., Kern S.E.

Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.

Cancer Res. 66:7920-7928(2006)

 

PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895

Pilarsky C., Ammerpohl O., Sipos B., Dahl E., Hartmann A., Wellmann A., Braunschweig T., Lohr J.-M., Jesenofsky R., Friess H., Wente M.N., Kristiansen G., Jahnke B., Denz A., Ruckert F., Schackert H.K., Kloppel G., Kalthoff H., Saeger H.-D., Grutzmann R.

Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling.

J. Cell. Mol. Med. 12:2823-2835(2008)

 

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928

Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

Cancer Sci. 99:986-994(2008)

 

CLPUB00416

Oberlin L.

Treatment of pancreatic carcinoma cell lines in vitro and vivo with a monoclonal antibody against the transferrin receptor.

Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany

 

PubMed=20037478; DOI=10.4161/cbt.8.21.9685; PMCID=PMC2824894

Kent O.A., Mullendore M.E., Wentzel E.A., Lopez-Romero P., Tan A.-C., Alvarez H., West K.M., Ochs M.F., Hidalgo M., Arking D.E., Maitra A., Mendell J.T.

A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.

Cancer Biol. Ther. 8:2013-2024(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20418756; DOI=10.1097/MPA.0b013e3181c15963; PMCID=PMC2860631

Deer E.L., Gonzalez-Hernandez J., Coursen J.D., Shea J.E., Ngatia J., Scaife C.L., Firpo M.A., Mulvihill S.J.

Phenotype and genotype of pancreatic cancer cell lines.

Pancreas 39:425-435(2010)