HSC-T6

HSC-T6/HSC-T6细胞系/HSC-T6细胞株/HSC-T6大鼠肝星形细胞

Cell line name    HSC-T6
Synonyms    HSCT6
Accession    CVCL_0315
Resource Identification Initiative    To cite this cell line use: HSC-T6 (RRID:CVCL_0315)
Comments    Doubling time: 10 hours (PubMed=26300973).
Karyotypic information: 43,XX,der(1),+4,+7,-12,+mar (PubMed=35681478).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptome analysis by RNAseq.
Caution: Was originally (PubMed=10828080) reported to be established from a male rat, but was later shown (PubMed=35681478) to have a female karyotype.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatic stellate cell; CL=CL_0000632.
Species of origin    Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS:0000681.
Sex of cell    Female
Age at sampling    Adult
Category    Transformed cell line
Publications    
PubMed=10828080; DOI=10.1016/S0022-2275(20)32030-7
Vogel S., Piantedosi R., Frank J., Lalazar A., Rockey D.C., Friedman S.L., Blaner W.S.
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.
J. Lipid Res. 41:882-893(2000)

PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x; PMCID=PMC3823251
Herrmann J., Gressner A.M., Weiskirchen R.
Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
J. Cell. Mol. Med. 11:704-722(2007)

PubMed=26300973; DOI=10.1186/s13069-015-0032-y; PMCID=PMC4546255
Stone L.C., Thorne L.S., Weston C.J., Graham M., Hodges N.J.
Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling.
Fibrogenesis Tissue Repair 8:15.1-15.15(2015)

PubMed=35681478; DOI=10.3390/cells11111783; PMCID=PMC9179542
Nanda I., Steinlein C., Haaf T., Buhl E.M., Grimm D.G., Friedman S.L., Meurer S.K., Schroder S.K., Weiskirchen R.
Genetic characterization of rat hepatic stellate cell line HSC-T6 for in vitro cell line authentication.
Cells 11:1783.1-1783.21(2022)